Meralco to raise rates by P0.47/kWh in Nov

Credit to Author: THE MANILA TIMES| Date: Thu, 07 Nov 2019 09:38:40 +0000

MANILA Electric Co. (Meralco) will raise its rates by P0.4717 per kilowatt hour (kWh) in November, a month after implementing a slight adjustment.

In a statement on Thursday, Meralco said the adjustment brings overall prices to P9.5579  per kWh this month from P9.0862 per kWh in October.

Households that consume 200 kWh will have an increase of P94.34 in their monthly bill; a 300-kWh consumption, P141.51; 400 kWh, P188.68; and 500 kWh, P235.85.

“Despite the adjustment, electricity rates this month are still almost P1 per kWh lower than in April 2019,” Meralco said. JORDEENE B. LAGARE

 

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Zooming into cilia sheds light into blinding diseases

In the current study, researchers reported the development and application of new imaging methods that provided a higher resolution view of the internal structure of normal and diseased retinal cilia. They discovered previously unknown compartments within the cilia and the location of some of the proteins involved in retinal disease. Their findings contribute to a better understanding of the structural defects leading to cilia-related blindness and open the door to developing future therapies.

“There is a large group of diseases called ciliopathies that are caused by genetic defects in the components of the structure of cilia. One the most common symptoms of ciliopathies is retinal degeneration and blindness, such as seen in retinitis pigmentosa and Bardet-Biedl syndrome,” said corresponding author Dr. Theodore G. Wensel, professor and Robert A. Welch Chair in Chemistry in the Department of Biochemistry at Baylor.

Wensel and his colleagues wanted to better understand how the genetic defects liked to retinal ciliopathies affected the structure of the cilia. But cilia are tiny, and the methods that have traditionally been used to study structural changes do not have enough resolution to reveal details of cilia internal structure.

“We wanted to look inside cilia to see how the molecules known to be involved in the disease caused the defects,” Wensel said. “We developed new methods — cryoelectron tomography and STORM (super-resolution stochastic optical reconstruction microscopy) — that provided a nanoscale view of the internal structure of the cilia. We worked with normal mice and mouse models of the human disease, Bardet-Biedl syndrome.”

The researchers applied these methods first to determine the structure of cilia in normal retina and found sub-compartments that had not been seen before. When they applied their higher resolution techniques to diseased retinas, they were able to pinpoint a more precise location of proteins associated with the condition.

“Before, we could say that a particular protein encoded by a disease gene was located at the cilium. Now we can say that it is located in the center of the axon, which is a tiny structure located in the center of the cilium, or in another of the newly discovered compartments,” Wensel said.

The researchers also discovered that some of the genetic defects alter the location of some of the proteins in the structure, and this information can potentially be useful to design therapies.

“Our findings provide a more detailed look at the structural changes associated with cilia defects in Bardet-Biedl syndrome. Our hope is that by understanding the disease mechanisms better we can develop therapies for this and other related conditions,” Wensel said.

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